https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32515 M. alba stem bark. Nephrotoxicity was induced with administration of paracetamol. Nephroprotection was studied using two doses of the extract. The experimental animals were divided into four groups (n = 6). Two groups served as positive and negative controls, respectively, and two received the test substances. All of the contents were orally administered. Significant reductions in nephrotoxicity and oxidative damages were observed in the treatment groups. There was a marked decrease in blood levels of urea, creatinine, and lipid peroxidation. Furthermore, it was found that glutathione levels in the blood increased dramatically after treatment. Histological findings confirmed the potent renoprotective potential of moralbosteroid. This was evidenced by the minimized intensity of nephritic cellular destruction. In animal studies, moralbosteroid exhibited dose-dependent activity, which is thought to be mediated through its antioxidant potential.]]> Wed 13 Jun 2018 11:02:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29589 Wed 11 Apr 2018 14:43:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25148 Sat 24 Mar 2018 07:17:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23804 Sat 24 Mar 2018 07:12:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48812 3) can be considered the most potent natural germicide against microorganisms (in vegetative and spore forms) with high efficiency and speed, because of its highly oxidizing activity. Despite this, there are a few studies describing the application of ozone as a sterilizing agent of medical devices. The aim of this communication was to describe the development and validation of a sterilization cycle applied to medical devices. Methods: The sterilization process was challenged using Geobacillus stearothermophilus ATCC 7953 spores, which have shown great resistance. The sterilizing effect of ozone was measured using carriers inoculated with 10⁶CFU/mL spores, introduced into a 3-mL syringe and lumens of tubes of different sizes and diameters simulating hospital medical products, which have undergone a half-cycle or complete cycle. Results: The results of sterilization process studied in active vegetative form of microorganisms showed that the ozone sterilization was effective with a bioburden between 10⁵ to 10⁷ CFU/mL with one pulse sterilizing action. The validation of the process was confirmed by the satisfactory results for the half-cycle, corresponding to a treatment with four pulses allowed sterilizing the material with bioburdens < 10⁶CFU/mL spores which indicate an appropriate sterility assurance level. Conclusion: The results showed that the ozone may be considered as effective and promising alternative for sterilization of thermosensitive materials and medical devices.]]> Mon 10 Apr 2023 10:21:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32346 Fri 25 May 2018 13:33:06 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32349 Fri 25 May 2018 13:33:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32348 Fri 25 May 2018 13:33:01 AEST ]]>